Research & Evidence
The evidence behind the standard.
The CLLP was not built on intuition. Every competency domain, every examination item, and every curriculum decision is grounded in peer-reviewed research on the chronically critically ill patient, on the clinical outcomes and workforce dynamics of the settings that care for them, and on the regulatory policy that governs those settings. This library curates the evidence that matters most to LTACH leaders, summarized in plain language, connected to practice, and updated as new evidence warrants.
The research gathered here represents the strongest available evidence base for understanding the challenges LTACH leaders face and the strategies that address them. It is not a comprehensive academic database — it is a practitioner-facing digest, curated by the LTACH Leadership Institute to inform the profession it serves.
Survival, Function, and Cognition After LTACH Hospitalization
This 2024 study in JAMA Network Open followed middle-aged and older adults after a stay in a long-term acute care hospital, a setting that serves more than 70,000 Medicare beneficiaries each year. The researchers linked the nationally representative Health and Retirement Study to Medicare claims, identifying 396 participants over age 50 who were admitted to an LTACH between 2003 and 2016, with a median age of 75. Half had experienced a prolonged ICU stay, and 41 percent had received mechanical ventilation. Within two and a half years of the LTACH admission, four in five had died or were living with severe impairment, defined as dependence in two or more activities of daily living or dementia. Health before the illness mattered: participants with a better survival prognosis and better function and cognition before the hospitalization had more favorable outcomes. The authors conclude that a patient's pre-hospitalization health can guide patients, families, and clinicians in decisions about prolonged acute care.
Time in Prior Hospital Stay and Ventilator Patient Outcomes in LTACHs
Focusing on one of the LTACH's most clinically demanding populations — patients requiring prolonged mechanical ventilation — this study examined how the timing of transfer from an acute care hospital affects outcomes in the LTACH setting. The research addresses a question that every LTACH clinical leader navigates in the context of admission decisions: who should be transferred, and when. The findings contribute evidence to decisions that are currently made largely on clinical judgment and that have significant implications for both patient outcomes and facility financial performance.
Patient Outcomes and Lessons Learned From Treating COVID-19 at an LTACH
This single-center retrospective study documented the characteristics, clinical management, and outcomes of patients treated for severe COVID-19 at an LTACH in the northeastern United States — and compared them to the facility's pre-pandemic medically complex patient population. The study illustrates the LTACH's role as a flexible, high-acuity resource in healthcare system surge management, and offers operational and clinical lessons relevant to any LTACH leader navigating a system-level crisis. The interdisciplinary care approach described reflects the kind of coordinated leadership that the CLLP's patient experience and clinical operations domains develop.
Palliative Care Services in Long-Term Acute Care Hospitals: A National Survey Study
This 2025 survey went directly to LTACH leaders to map how palliative care actually operates inside these facilities. Among responding hospitals, 57% reported having a palliative care program, but the more useful finding for executives is why the others didn't: leaders named difficulty recruiting staff, financing, limited leadership support, and uncertainty about the benefit as the main barriers. Hospitals with a program were more often embedded within a larger health system that supplied leadership and financial backing.
Nursing Staff Turnover and Care Quality in Hospital Units
This peer-reviewed study examined the relationship between nurse staffing levels, collective staff turnover, and care quality across hospital units — finding that nurse turnover negatively affects care quality for intensive care units and medical-surgical units, with the impact more substantial in higher-acuity settings. For LTACH leaders — who manage both high-acuity clinical environments and chronic workforce instability — the findings quantify what experienced operators already know: turnover is not just a human resources problem. It is a patient safety problem. Increased staffing levels are identified as an effective countermeasure, but the study acknowledges the operational constraints that make this solution more complex in practice.
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Contributing to the Evidence Base
The LTACH sector is under-researched relative to its clinical complexity and the demands it places on its leaders. The LTACH Leadership Institute actively monitors the peer-reviewed literature across the five research categories above and updates this library as new evidence warrants. We also invite LTACH practitioners and researchers to suggest relevant research for inclusion. If you are a researcher whose work addresses LTACH clinical outcomes, workforce dynamics, regulatory policy, leadership development, or financial sustainability — and you believe it would be valuable to the LTACH practitioner community — contact us at research@LTACHLeadershipInstitute.org.
