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Research & Evidence

The evidence behind the standard.

The CLLP was not built on intuition. Every competency domain, every examination item, and every curriculum decision is grounded in peer-reviewed research on LTACH clinical outcomes, workforce dynamics, regulatory policy, and leadership development in high-acuity care environments. This library curates the evidence that matters most to LTACH leaders — summarized in plain language, connected to practice, and updated quarterly.

The research gathered here represents the strongest available evidence base for understanding the challenges LTACH leaders face and the strategies that address them. It is not a comprehensive academic database — it is a practitioner-facing digest, curated by the LTACH Leadership Institute to inform the profession it serves.

Clinical Outcomes

Survival, Function, and Cognition After LTACH Hospitalization

Jain S, Gan S, Nguyen OK, et al. Survival, Function, and Cognition After Hospitalization in Long-Term Acute Care Hospitals. JAMA Network Open. 2024;7(5):e2413309.

This 2024 JAMA Network Open study examined the longer-term outcomes of middle-aged and older adults after hospitalization in long-term acute care hospitals — tracking survival, functional status, and cognitive function following discharge. The findings document what LTACH clinicians observe daily: the patients who enter these facilities carry a profound burden of illness, and recovery — when it occurs — is hard-won and requires sustained, high-level care coordination. The study contributes meaningful outcome data to a setting that has historically been under-represented in clinical research.

Editorial Note

Understanding outcomes data is not just a clinical responsibility — it is a leadership one. LTACH leaders who can interpret and communicate this data to families, referral sources, and boards lead more credible organizations.

Clinical Outcomes

Time in Prior Hospital Stay and Ventilator Patient Outcomes in LTACHs

Demiralp B, Koenig L, Xu J, et al. Time spent in prior hospital stay and outcomes for ventilator patients in long-term acute care hospitals. BMC Pulmonary Medicine. 2021;21:100.

Focusing on one of the LTACH's most clinically demanding populations — patients requiring prolonged mechanical ventilation — this study examined how the timing of transfer from an acute care hospital affects outcomes in the LTACH setting. The research addresses a question that every LTACH clinical leader navigates in the context of admission decisions: who should be transferred, and when. The findings contribute evidence to decisions that are currently made largely on clinical judgment and that have significant implications for both patient outcomes and facility financial performance.

Editorial Note

Admission decision-making is one of the highest-stakes operational responsibilities in the LTACH. The CLLP's clinical operations domain addresses exactly this — giving leaders the framework to evaluate these decisions with rigor rather than intuition alone.

Clinical Outcomes

Patient Outcomes and Lessons Learned From Treating COVID-19 at an LTACH

Grevelding P, Hrdlicka HC, Holland S, et al. Patient Outcomes and Lessons Learned From Treating Patients With Severe COVID-19 at a Long-term Acute Care Hospital. JMIR Formative Research. 2022;6(2):e31502.

This single-center retrospective study documented the characteristics, clinical management, and outcomes of patients treated for severe COVID-19 at an LTACH in the northeastern United States — and compared them to the facility's pre-pandemic medically complex patient population. The study illustrates the LTACH's role as a flexible, high-acuity resource in healthcare system surge management, and offers operational and clinical lessons relevant to any LTACH leader navigating a system-level crisis. The interdisciplinary care approach described reflects the kind of coordinated leadership that the CLLP's patient experience and clinical operations domains develop.

Editorial Note

Crisis readiness is a leadership competency, not just a clinical one. LTACH leaders who understand how to mobilize interdisciplinary teams under surge conditions protect both their patients and their organizations.

Workforce & Retention

Palliative Care Services in Long-Term Acute Care Hospitals: A National Survey Study

Makam AN, O'Riordan DL, Heitner R, Bowman B, Spetz J, Pantilat SZ. Palliative Care Services in Long-Term Acute Care Hospitals: A National Survey Study. J Pain Symptom Manage. 2025. https://doi.org/10.1016/j.jpainsymman.2025.03.009

This 2025 survey went directly to LTACH leaders — members of the National Association of Long Term Hospitals — to map how palliative care actually operates inside these facilities. Among responding hospitals, 57% reported having a palliative care program, but the more useful finding for executives is why the others didn't: leaders named difficulty recruiting staff, financing, limited leadership support, and uncertainty about the benefit as the main barriers. Hospitals with a program were more often embedded within a larger health system that supplied leadership and financial backing.

Editorial Note

This is a rare study that asks LTACH leaders themselves what stands in the way. The barriers it surfaces — staffing, financing, and leadership support — are precisely the levers an executive controls. It reframes a clinical service as an outcome of leadership decisions.

Workforce & Retention

Nursing Staff Turnover and Care Quality in Hospital Units

Peng J, et al. The impact of nurse staffing on turnover and quality: An empirical examination of nursing care within hospital units. Journal of Operations Management. 2023.

This peer-reviewed study examined the relationship between nurse staffing levels, collective staff turnover, and care quality across hospital units — finding that nurse turnover negatively affects care quality for intensive care units and medical-surgical units, with the impact more substantial in higher-acuity settings. For LTACH leaders — who manage both high-acuity clinical environments and chronic workforce instability — the findings quantify what experienced operators already know: turnover is not just a human resources problem. It is a patient safety problem. Increased staffing levels are identified as an effective countermeasure, but the study acknowledges the operational constraints that make this solution more complex in practice.

Editorial Note

LTACH leaders who understand the quantified relationship between turnover and outcomes make better business cases for retention investment. Financial acumen and workforce leadership are the same competency in this context.

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Contributing to the Evidence Base

The LTACH sector is under-researched relative to its clinical complexity and the demands it places on its leaders. The LTACH Leadership Institute actively monitors the peer-reviewed literature across the five research categories above and updates this library quarterly. We also invite LTACH practitioners and researchers to suggest relevant research for inclusion. If you are a researcher whose work addresses LTACH clinical outcomes, workforce dynamics, regulatory policy, leadership development, or financial sustainability — and you believe it would be valuable to the LTACH practitioner community — contact us at research@LTACHLeadershipInstitute.org.